How Vagifem® works in your body.

Vagifem® (estradiol vaginal inserts) 10 mcg is placed directly into the vagina, right where you’re experiencing changes, to help replenish estrogen lost due to menopause.

Vagifem® estradiol vaginal inserts can help alleviate uncomfortable symptoms due to menopause

Vagifem® is the same as the body’s estrogen.

Not all estrogens are the same; there are several different forms of estrogens. The estrogen used in Vagifem® 10 mcg is called “estradiol,” which is the same estrogen that your body makes.

Even with estradiol, moderation is important. The North American Menopause Society (NAMS) recommends that women take the lowest effective dose of estrogen consistent with the treatment goals their health care provider has established.

Administer estradiol tabs directly into your vagina, where the symptoms are present
Vagifem® 10 mcg estradiol insert

Treatment given where it's needed.

Vagifem® 10 mcg is an insert that you place in your vagina with a convenient, predosed, single-use applicator made of smooth plastic. To help ensure exact dosing, each applicator contains a single insert with 1 dose of Vagifem® 10 mcg.

You can insert the Vagifem® 10 mcg insert with the slim applicator while standing up or lying down. You don’t need to wash and reuse the applicator; just dispose of it after use, as you would a tampon applicator. Learn more about how to take it, or read the complete instructions for taking Vagifem® in the Patient Information.

Our single-use vaginal applicator makes administering menopause medicine easier
Our menopause treatment comes in a single-use vaginal applicator Our hormonal therapy may help ease menopausal symptoms, such as dry vagina Discomfort due to a hormonal imbalance can be alleviated with Vagifem® Insert the vaginal applicator directly into the vagina to administer Vagifem® 10 mcg estradiol vaginal inserts

How often to take it.

During the first 2 weeks of treatment, you’ll use 1 Vagifem® 10 mcg insert every day; then 1 insert twice weekly thereafter (for example, Tuesday and Friday), as prescribed by your health care provider. Click here to see an example of the dosing schedule.

Good to know:

After the first 2 weeks of treatment, you’ll use Vagifem® 10 mcg less frequently—and possibly reduce your out-of-pocket cost, too.

What Vagifem® treats.

Vagifem® 10 mcg treats menopausal symptoms in and around the vagina.

Clinical studies showed that Vagifem® 10 mcg reduced a combined score of the most bothersome symptoms, including:

  • Vaginal dryness
  • Pain and bleeding during intercourse
  • Irritation
  • Soreness
  • Itching in and around the vagina
  • Painful urination

Vagifem® 10 mcg treats the underlying cause of menopause-related vaginal changes by helping to replenish the vagina’s lost estrogen.