Vagifem® is a local estrogen therapy.

Vagifem® (estradiol vaginal inserts) 10 mcg delivers treatment directly to the vagina. It’s a local estrogen treatment—not to be confused with systemic hormone replacement therapy.

Just what is estrogen?
Estrogen is a hormone responsible for changes in the vagina and uterus. There are several forms of estrogen, including estradiol, which is used in several LETs; another LET uses conjugated, or combined, estrogens.

What is local estrogen therapy?

“Local” means that the treatment is applied directly to the affected area—in this case, the vagina. Local delivery of estrogen:

  • Results in quantifiably lower doses of estrogen than systemic estrogen treatments

  • Limits the amount of estrogen a woman may be exposed to

Compare local estrogen therapy to other types of treatment used to treat vaginal symptoms that happen after menopause, and ask your health care provider to discuss local estrogen therapy with you.

The molecular structure of estradiol:
exactly the same as what your body makes.
The molecular structure of estradiol

Local Estrogen Therapies

Brand of LET How It's Taken How Mucha
& How Often
Type of Estrogen Dose Strength
Vagifem® (estradiol vaginal inserts) 10 mcg
Vagifem® (estradiol vaginal inserts) 10 mcg Insert inserted into the vagina 1 insert daily for 2 weeks; then twice weekly going forward Estradiol Each insert contains 10 mcg (0.01 mg) estradiol
Estring® (estradiol vaginal ring)
Estring® (estradiol vaginal ring) Ring inserted into the vagina 1 ring every 3 months Estradiol Each ring contains 2 mg estradiol (releasing approximately 0.75 mcg [0.0075 mg] per day)
Estrace® (estradiol vaginal cream)
Estrace® (estradiol vaginal cream) Cream inserted into the vagina The usual dosage range is 2 to 4 g (marked on the applicator) daily for 1 or 2 weeks, then gradually reduced to one-half initial dosage for a similar period. A maintenance dosage of 1 g, 1 to 3 times a week, may be used after restoration of vaginal mucosa has been achieved. Estradiol Each gram contains 0.1 mg (100 mcg) estradiol
Premarin® (conjugated estrogens) vaginal cream
Premarin® (conjugated estrogens) vaginal cream Cream inserted into the vagina ½ gram daily for 3 weeks, then off for 1 week; repeat. Conjugated estrogens (a combination of different estrogens) Each gram contains 0.625 mg (625 mcg) conjugated estrogens
Imvexxy® (estradiol vaginal inserts) 4 mcg or 10 mcg
Imvexxy® (estradiol vaginal inserts) 4 mcg or 10 mcg Insert (softgel capsule) inserted into the vagina 1 insert (softgel capsule) daily for 2 weeks, then twice weekly going forward Estradiol Each insert (softgel capsule) contains either 4 mcg (0.004 mg) or 10 mcg (0.01 mg) estradiol

a Please see Prescribing Information for related products. The dose listed is the lowest recommended dose according to each product’s Prescribing Information. Dosing regimen may vary depending upon symptoms.

The above chart is not intended to be a comparison of efficacy and safety.